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CHE 008B A01 SS1 2025 Lecture 14 - Claisen Condensation
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Assign each of these statements as True or False. True Intramolecular Claisen condensations prefer 5 or 6 member rings. False Using a ketone as an enolate in a Claisen condensation gives a beta-diester. True Claisen condensations require 1 or more alpha H to form an enolate ion nucleophile to give a good yield. True The product of a Claisen condensation is more acidic than the starting material.
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We begin by restating the four statements to be evaluated, then we assess each one in turn with explanations and examples where helpful.
Statement 1: 'Intramolecular Claisen condensations prefer 5 or 6 member rings.'
- Intramolecular Claisen (often described as a Dieckmann-type condensation when intramolecular) tends to cyclize to form ring products. Ring size is governed by the distance between the reacting carbonyls and the nucleophilic carbon, and five- and six-membered rings......Login to view full explanationLog in for full answers
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Which of these could be a nucleophile for a Claisen Condensation? (select all that apply)
The Claisen condensation first forms an ion which undergoes a to give the beta-ketoester. This product immediately undergoes an acid base reaction because it's pKa is about which is favored over the ester who's pKa is about .
The Claisen condensation is analogous to the reaction of aldehydes but with esters.
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