In the first step of the citric acid cycle, it is important that side reactions such as undesired hydrolysis to release _____ be minimized.

Question

BlackTom AI · Accepted Answer

Careful reading of the question focuses on keeping side reactions from happening in the initial step of the citric acid cycle.
Option 1: oxaloacetate. This is a reactant that combines with acetyl-CoA to form citrate, so an undesired hydrolysis to oxaloacetate would not make sense here. It is not the product of a hydrolysis event in this step.
Option 2: pyruvate. Pyruvate is a metabolite upstream of the cycle (from glycolysis) and is not a product or a target of hydrolysis in the first step of the CAC. Its involvement would imply an entirely different pathway influence, not a hydrolysis product at this stage.
Option 3: succinate. Succinate appears later in the cycle after several steps; it is not the immediate product or a likely hydrolysis byproduct of the first condensation reaction. Thus, it does not fit as the undesired hydrolysis product in step one.
Option 4: acetate. This is the correct focus for the stated concern. The first step would ideally preserve the acetyl group attached to CoA; undesired hydrolysis would release acetate, wasting the acetyl unit and disrupting the energy yield from acetyl-CoA processing.
Option 5: citrate. Citrate is the direct product of the condensation of acetyl-CoA with oxaloacetate in the first step, not a hydrolytic byproduct. While citrate formation is key, the question concerns avoiding hydrolysis to release a simple acetate unit, which would be a misdirection here.
In summary, minimizing hydrolysis to release acetate safeguards the acetyl group for entry into the cycle, whereas the other options either represent reactants, downstream intermediates, or products that are not associated with that specific undesired hydrolysis pathway.

In the first step of the citric acid cycle, it is important that side reactions such as undesired hydrolysis to release _____ be minimized.

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