Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

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Question: Which of the following is NOT an example of a receptor tyrosine kinase?

Option a: A Fibroblast growth factor receptor
This is a classic receptor tyrosine kinase (RTK). FGFRs have an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular tyrosine kinase domain that autophosphorylates upon ligand binding.

Option b: An Interleukin 1 receptor
This receptor does not possess intrinsic tyrosine kinase activity. IL-1 receptor signaling occurs via adaptor proteins like MyD88 and downstream kinases such as IRAK, leading to NF-κB activation. It is not classified as an RTK.

Option c: A vascular endothelial growth factor receptor
VEGFRs are well-known RTKs with extracellular ligand binding, a single transmembrane segment, and an cytoplasmic tyrosine kinase domain that becomes activated upon ligand binding.

Option d: An insulin receptor
The insulin receptor is a prototypical RTK. It auto-phosphorylates on tyrosine residues and propagates signaling through pathways like PI3K-AKT and MAPK.

Summary: Options a, c, and d are all receptor tyrosine kinases, each possessing an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyrosine kinase domain, and they propagate signals via tyrosine phosphorylation. Option b lacks intrinsic tyrosine kinase activity and uses adaptor proteins for signal transduction, so it is not an RTK.

Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

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Which of the following is NOT an example of a receptor tyrosine kinase?[Fill in the blank]

View Explanation

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