G protein receptor is a

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The question presents a statement about G protein receptors and asks you to evaluate the options.
Option 1: 'Second messenger receptor' — This aligns with the widely taught mechanism where a ligand binds a G protein-coupled receptor (GPCR) and triggers intracellular signaling cascades that generate second messengers (such as cAMP, IP3, DAG, Ca2+). The receptor itself is the initial site of signal detection, but its activation leads to the production or modulation of second messengers, which then propagate the signal inside the cell. This option captures the link between GPCR activation and downstream second messenger systems, making it the correct conceptual match here.
Option 2: 'Third messenger receptor' — There is no standard concept of a 'third messenger' in cellular signaling that corresponds to GPCRs. Signaling cascades commonly involve first messengers (external ligands) and second messengers; introducing a 'third messenger' would add an unnecessary or incorrect layer without a defined, widely accepted counterpart in this context. This makes the statement inaccurate.
Option 3: 'First messenger receptor' — The term 'first messenger' is typically used to describe the extracellular ligand that initiates signaling, not the receptor itself. A receptor is the detector of the first messenger, rather than being characterized as the first messenger receptor. While the receptor interacts with first messengers, labeling the receptor itself as the 'first messenger receptor' is misleading and does not reflect standard terminology.
Option 4: 'Fourth messenger receptor' — Similar to the third messenger idea, there is no recognized 'fourth messenger' in canonical signaling language for GPCR pathways. Introducing a 'fourth messenger' lacks basis in established biology and would be considered incorrect.
In summary, the statement that a G protein receptor is a second messenger receptor best fits the perspective that GPCR activation leads to downstream second messenger signaling, while the other options introduce nonstandard terminology or conceptual mismatches that do not align with established signaling frameworks.

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G protein receptor is a

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