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CHE 008B A01 SS1 2025 Lecture 7 - Carbonyl Reductions with Hydride

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Which of these are True / False False Cyanhydrin formations are irreversible. True Pd and H2, Ni and H2, or NaBH3CN in acid can be used to reduce imines or enamines to amines. True Hydrolysis of cyanohydrins gives alpha-hydroxycarboxylic acids in acid and alpha-hydroxycarboxylate ions in base. True Good nucleophiles that are moderate bases can add reversibly to carbonyls because the reformation of the C=O bond is favorable.

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The question asks us to evaluate four statements as True or False and then provides the given answers. I will assess each statement on its own merits and explain why it is true or false. Statement 1: 'False Cyanohydrin formations are irreversible.' - In general, cyanohydrin formation from a carbonyl compound and HCN (or a cyanide source) is equilibrium-controlled and reversible under many conditions. The cyanohydrin can revert back to the carbonyl compound and HCN, especially if water or other reagents shift the equilibrium. Therefore declaring cyanohydrin formation as irreversib......Login to view full explanation

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