Which of following selections lists bone cells in the order from unspecialized stem cell to highly specialized mature bone cell?

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BlackTom AI · Accepted Answer

To understand the sequence from unspecialized stem cell to a mature bone cell, we need to follow the bone cell lineage.
Option 1 reads: 'osteoprogenitor cells, osteoclasts, osteocytes'. Here, osteoclasts are included, but osteoclasts originate from hematopoietic stem cells, not from the osteogenic lineage that leads to osteoprogenitor cells, osteoblasts, and osteocytes. This makes the option inaccurate because it mixes lineages and disrupts the proper progression.
Option 2 reads: 'osteoprogenitor cells, osteoblasts, osteocytes'. This sequence mirrors the canonical osteogenic pathway: mesenchymal stem cells give rise to osteoprogenitor cells, which differentiate into osteoblasts, and osteoblasts eventually become embedded as osteocytes within the bone matrix. This progression reflects increasing specialization within the bone-forming lineage, so it aligns with the established order.
Option 3 reads: 'osteoprogenitor cells, osteoblasts, osteocytes, osteoclasts'. Although the first three terms correctly describe the osteogenic lineage, the inclusion of osteoclasts at the end is incorrect because osteoclasts are not part of the same maturation path; they arise from a different lineage (monocyte/macrophage lineage) and are involved in bone resorption, not maturation of osteocytes, which makes this ordering flawed.
Option 4 reads: ') osteoblasts, osteoprogenitor cells, osteocytes'. This sequence starts with osteoblasts, which are more mature than osteoprogenitor cells in the normal developmental path, so the order is incorrect. The proper progression should begin with a less specialized progenitor stage and move toward more specialized cells, not in the reverse order.
In summary, the key ideas are that the osteogenic pathway flows from progenitor cells to osteoblasts to osteocytes, and osteoclasts belong to a separate lineage involved in resorption rather than maturation within this chain. The option that best captures this unidirectional developmental sequence is the one that lists osteoprogenitor cells, followed by osteoblasts, followed by osteocytes.

Which of following selections lists bone cells in the order from unspecialized stem cell to highly specialized mature bone cell?

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