During bi-phasic cell culture growth in a bioreactor:

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BlackTom AI · Accepted Answer

In the context of bi-phasic cell culture growth in a bioreactor, the key idea is that the culture undergoes two distinct growth phases, each often requiring different environmental conditions to optimize cell growth and product formation.

Option provided: 'different growth conditions are provided during early and late stages of growth.' This statement aligns with the fundamental concept of biphasic growth, where the first phase may emphasize promoting cell proliferation (e.g., providing adequate nutrients, optimal pH, temperature, and oxygen transfer), while the second phase may shift toward supporting cell differentiation, product formation, or stress adaptation (which could involve altered feed strategies, oxygen levels, or nutrient ratios). The rationale is that cells have phase-specific needs, and a biphasic approach explicitly acknowledges transitioning conditions to match those needs.

Consider why this makes sense: during early growth, cells prioritize biomass accumulation, which benefits from conditions that maximize division rates and viability. In the late phase, metabolic shifts occur, and conditions are often tuned to favor product synthesis, secretion, or maintenance of cell health under accumulated metabolic byproducts. Adopting different conditions at these stages can prevent nutrient depletion, limit inhibitory byproducts, and optimize overall culture performance.

If there were other options, one would expect them to claim that single, unchanging conditions suffice throughout the culture, or that all phases require identical parameters regardless of biological state. Such statements would conflict with the well-established practice of fed-batch and biphasic strategies, where dynamic adjustment of parameters is common. In this case, since no alternative options are provided to contrast, the single statement stands as the reflection of biphasic culture design.

In summary, recognizing that early and late growth stages demand distinct environmental settings embodies the core logic of biphasic culture strategies, supporting better control over growth kinetics and product outcomes.

BIOT5750.39480.202530 Module 5 Quiz S25

During bi-phasic cell culture growth in a bioreactor:

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