Question at position 65 ______________ decrease the activation of the sympathetic nervous system and reduce blood pressure and afterload.DigoxinARBsACE inhibitorsDiureticsBeta blockers

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Question restatement: The prompt asks which option will decrease the activation of the sympathetic nervous system and reduce blood pressure and afterload. Answer options: Digoxin, ARBs, ACE inhibitors, Diuretics, Beta blockers.
Option 1: Digoxin. This drug primarily increases cardiac contractility and has a role in heart failure management, but it does not directly decrease sympathetic activation or afterload; its main effects are on inotropy and conduction, not on systemic vascular resistance.
Option 2: ARBs (Angiotensin II Receptor Blockers). ARBs block angiotensin II receptors, which can reduce vasoconstriction and may lower blood pressure, but their primary mechanism is not a direct dampening of sympathetic nervous system activity; they reduce afterload indirectly by vasodilation.
Option 3: ACE inhibitors. ACE inhibitors decrease angiotensin II production, leading to vasodilation and reduced afterload, and they can lower blood pressure. Similar to ARBs, their main action is not a direct decrease in sympathetic nerve activity, but they do contribute to BP reduction through renin-angiotensin system suppression.
Option 4: Diuretics. Diuretics promote sodium and water excretion to reduce plasma volume, which lowers blood pressure and reduces preload; they have a less direct effect on sympathetic tone and afterload compared with beta blockers.
Option 5: Beta blockers. Beta blockers blunt the effects of sympathetic stimulation on the heart and vasculature, directly decreasing sympathetic outflow effects, lowering heart rate, contractility, and vasoconstriction, thereby reducing blood pressure and afterload.
In summary, while several antihypertensive classes can lower blood pressure and have secondary effects on sympathetic activity, Beta blockers are specifically well-known for directly decreasing sympathetic nervous system activation and reducing both blood pressure and afterload through those sympathetic-mediated pathways.

Question at position 65 ______________ decrease the activation of the sympathetic nervous system and reduce blood pressure and afterload.DigoxinARBsACE inhibitorsDiureticsBeta blockers

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