You discover a new compound that adversely affects the functioning of lysosomes. What might be the consequence of this compound when it is applied to cells?

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BlackTom AI · Accepted Answer

Consider the role of lysosomes in the cell. 
Option 1: 'mRNA transport out of the nucleus will be disrupted'—This process occurs in the nucleus and cytoplasm, not directly dependent on lysosomal function. Disrupting lysosomes would not typically block mRNA export, so this is unlikely to be the direct consequence. 
Option 2: 'Transit through the Golgi will be disrupted'—Golgi trafficking is part of the secretory pathway, largely separate from lysosomal degradation pathways. While cellular stress can influence trafficking globally, a primary lysosomal inhibitor would not necessarily halt Golgi transit as its defining effect. Therefore this is not the most direct consequence of lysosome impairment. 
Option 3: 'Autophagy will be disrupted'—Autophagy relies on the formation of autophagosomes that fuse with lysosomes for degradation of cellular components. If lysosomal function is impaired, autophagosomes cannot be efficiently degraded, leading to accumulation and disruption of autophagic flux. This is a direct and well-supported consequence. 
Option 4: 'Lipid synthesis in the ER will be disrupted'—Lipid synthesis occurs in the ER and is not the primary function of lysosomes. While cellular stress can have widespread effects, lysosomal dysfunction does not inherently block ER lipid synthesis as a direct outcome. This makes it an unlikely primary consequence. 
In summary, the most plausible and direct outcome of lysosome impairment is a disruption of autophagy due to failure of degradation within lysosomes, whereas the other options involve processes not primarily governed by lysosomal activity or are less direct effects of lysosome dysfunction.

Bio 93 Section CDE 2025 Midterm 1- Section E

You discover a new compound that adversely affects the functioning of lysosomes. What might be the consequence of this compound when it is applied to cells?

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