Questions

BPS3011 S1 2025 Weeks 10 AND 11 interactive lectures. Myocardial infarction pathophysiology and pharmacology

Matching

Can you get the order of events right? Match the description of each event with its name. 1: Next, something happens that causes white blood cells to enter the artery wall 2: Plaque is formed - made of foam cells, smooth muscle cells, collagen cap. This is bad because the 3: Monocytes now become activated - they change shape and become inflammatory because 4: Things can get worse though if the plaque ruptures because: 5: The early stages of atherosclerosis involve: 6: Activated monocytes (macrophages) release cytokines (e.g. interleukin 1) that cause

Options

A.Collagen and vWF in a ruptured plaque initiates the clotting cascade, causing a myocardial infarction

B.fibroblasts to make collagen and smooth muscle cells to migrate into the plaque

C.Proteins called ICAMs are expressed on endothelial cells - allowing monocytes an entry point to the wall

D.they engulf LDL-cholesterol, becoming "foam cells"

E.plaque now bulges out into lumen of the artery, altering flow, causing the painful condition known as angina pectoris

F.reactive oxygen species (ROS) and hypertension acting over many years cause changes to the endothelium less NO = more clotting and reduced dilation ROS oxidises LDL cholesterol (yellow dots with a cross below)

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Step-by-Step Analysis

Question restatement and options: - 1: Next, something happens that causes white blood cells to enter the artery wall ____ - 2: Plaque is formed - made of foam cells, smooth muscle cells, collagen cap. This is bad because the ____ - 3: Monocytes now become activated - they change shape and become inflammatory because ____ - 4: Things can get worse though if the plaque ruptures because: ____ - 5: The early stages of atherosclerosis involve: ____ - 6: Activated monocytes (macrophages) release cytokines (e.g. interleukin 1) that cause ____ Candidate answer options: A. Collagen and vWF in a ruptured plaque initiates the clotting cascade, causing a myocardial infarction B. fibroblasts to make collagen and smooth muscle cells to migrate into the plaque C. Proteins called ICAMs are expressed on endothelial cells - allowing monocytes an entry point to the wall D. they engulf LDL-cholesterol, becoming "foam cells" E. plaque now bulges out into lumen of the artery, altering flow, causing the painful condition known as angina pectoris F. reactive oxygen species (ROS) and hypertension acting over many years cause changes to the endothelium less NO = more clotting and reduced dilation ROS oxidises LDL cholesterol (y......Login to view full explanation

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