Let's first consider the Excedrin® Cullen is taking. How is the acetaminophen in Excedrin® helping treat Cullen's headache? Acetaminophen is:

Question

Let's first consider the Excedrin® Cullen is taking.  How is the acetaminophen in Excedrin® helping treat Cullen's headache?  Acetaminophen is:

BlackTom AI · Accepted Answer

When evaluating how acetaminophen works to relieve Cullen's headache, it's helpful to recall its mechanism and how it differs from other NSAIDs.
Option 1: 'Irreversibly inhibiting COX enzymes to relieve pain' is incorrect. Acetaminophen does not permanently inactivate COX enzymes; it does not act through irreversible inhibition like some other drugs do.
Option 2: 'Causing weak inhibition of COX enzymes to relieve pain' is correct. Acetaminophen achieves analgesia primarily through weak, reversible inhibition of COX enzymes, especially in the central nervous system, which lowers pain perception. It has minimal anti-inflammatory effects in the periphery.
Option 3: 'Preventing the inflammation in his brain to relieve pain' is misleading. Acetaminophen is not an anti-inflammatory drug in the conventional sense and does not directly prevent inflammation in the brain; its pain-relieving action is largely central and not due to reducing inflammatory processes like typical NSAIDs.
Option 4: 'None of the above' is incorrect because Option 2 accurately describes the mechanism as weak COX inhibition in the CNS leading to analgesia, not strong or irreversible inhibition.
In summary, acetaminophen provides pain relief mainly through weak, reversible COX inhibition in the central nervous system, with limited peripheral anti-inflammatory activity, which aligns with Option 2.

PHR 2410 SP2025 (36478) MODULE 2 | Case Study #1 - Part I

Let's first consider the Excedrin® Cullen is taking. How is the acetaminophen in Excedrin® helping treat Cullen's headache? Acetaminophen is:

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