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CHE 008B A01 SS1 2025 Lecture 14 - Reactions of Amides

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Determine if the following are True or False. False Amides react with most weakly basic nucleophiles to do nucleophilic acyl substitution. True Reduction of amides forms amines. False Only tertiary amides (RCONR2) can be reduced because LiAlH4 reacts with the N-H bond to form H2 gas. True Amide bonds are difficult to break with hydrolysis.

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The task presents four statements about amides and asks us to judge True or False for each. We'll examine each item in turn, noting why it is correct or incorrect and addressing common misconceptions along the way. Statement 1: 'False Amides react with most weakly basic nucleophiles to do nucleophilic acyl substitution.' - At first glance, many might think amides are quite reactive toward nucleophiles due to the carbonyl group, but the reality is that amide carbonyls are strongly resonance-stabil......Login to view full explanation

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