Question at position 65 Which is a correct match of term to definition?Sporadic Alzheimer's disease - occurs when beta-amyloid is affected more than tauEarly onset Alzheimer's disease - occurs when tau is affected more than beta-amyloidSporadic Alzheimer's disease - occurs in people over 65 years oldEarly onset Alzheimer's disease - occurs in people over 65 years old

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First, let's restate the question and the options to set the context for analysis.
Question at position 65: Which is a correct match of term to definition?
Options:
1) Sporadic Alzheimer's disease - occurs when beta-amyloid is affected more than tau
2) Early onset Alzheimer's disease - occurs when tau is affected more than beta-amyloid
3) Sporadic Alzheimer's disease - occurs in people over 65 years old
4) Early onset Alzheimer's disease - occurs in people over 65 years old

Now, evaluating each option:
Option 1: 'Sporadic Alzheimer's disease - occurs when beta-amyloid is affected more than tau'. This statement describes a scenario where beta-amyloid pathology is dominant. However, sporadic Alzheimer's disease is typically associated with amyloid accumulation (beta-amyloid) and is not strictly defined by the relative dominance of beta-amyloid over tau in all cases. Moreover, the term itself in standard definitions is more about sporadic versus familial, and age of onset is not the defining criterion here. So this formulation may be partially descriptive but is not the conventional or complete match for the term-definition pairing.
Option 2: 'Early onset Alzheimer's disease - occurs when tau is affected more than beta-amyloid'. This option emphasizes tau predominance over beta-amyloid as the defining feature of early onset Alzheimer's, which is not the standard distinguishing criterion. Early onset is typically defined by age of onset (generally before ~65), and both beta-amyloid and tau pathologies can be involved; tau predominance is not the recognized defining characteristic for early onset. Therefore this option misstates the canonical definition.
Option 3: 'Sporadic Alzheimer's disease - occurs in people over 65 years old'. This matches the common epidemiological distinction: sporadic (non-familial) Alzheimer's disease predominantly presents in older adults, typically over 65. While there are nuances in pathology, this option correctly aligns the term sporadic with the age-related occurrence pattern, making it a proper term-definition pairing in the context of basic terminology.
Option 4: 'Early onset Alzheimer's disease - occurs in people over 65 years old'. This is inconsistent because early onset is defined by age of onset (usually before 65). Stating that it occurs in people over 65 contradicts the standard definition of early onset and thus is incorrect.

In summary, Option 3 presents the accurate, conventional pairing: sporadic Alzheimer's disease is associated with occurrence in people over 65. The other options either confuse the pathophysiological emphasis (beta-amyloid vs tau) or misalign the age-based definition of early onset, leading to incorrect matches.

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