Look at each of the given compounds and determine if they would be a nucleophile only, an electrophile only, both, or neither for an aldol condensation. Compound A: electrophile only Compound B: nucleophile only Compound C: both an electrophile and a nucleophile Compound D: neither Compound E: both an electrophile and a nucleophile Compound F: nucleophile only

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Understanding aldol condensation helps determine whether a compound acts as an electrophile, a nucleophile, both, or neither. Key ideas: - The electrophile in an aldol reaction is typically a carbonyl compound (aldehyde or ketone) whose carbonyl carbon can be attacked by a nucleophile. - The nucleophile in an aldol reaction is usually an enolate or an enolizable species that can form a negatively charged carbon (or a highly nucleophilic center) to attack the electrophile. - A molecule can act as an electrophile, a nucleophile, both, or neither depending on its structural features (presence of a carbonyl group for electrophilicity and presence of ......Login to view full explanation

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