Question23 What does George Koob mean by the term ‘drug-generated sensitization of anti-reward’? Repeated drug use decreases the rewarding properties of the drug Repeated drug use increases the symptoms of withdrawal and tolerance (an aversive state) Repeated drug use increases the rewarding properties of the drug Repeated drug use decreases the symptoms of withdrawal and tolerance (an aversive state) ResetMaximum marks: 1.5 Flag question undefined

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BlackTom AI · Accepted Answer

When approaching this question, I first map the term drug-generated sensitization of anti-reward to Koob’s framework, which links repeated drug exposure to an enhanced aversive state rather than increased drug reward alone.
Option 1: 'Repeated drug use decreases the rewarding properties of the drug' — This would mean tolerance to reward, but Koob’s anti-reward sensitization emphasizes an escalating negative affect, not simply reduced pleasure from the drug. So this option misaligns with the anti-reward concept.
Option 2: 'Repeated drug use increases the symptoms of withdrawal and tolerance (an aversive state)' — This aligns with anti-reward sensitization, where the brain's stress and negative affect systems become more active, intensifying withdrawal symptoms and perceived aversiveness, which drives continued use to alleviate these states.
Option 3: 'Repeated drug use increases the rewarding properties of the drug' — This directly contradicts the idea of anti-reward sensitization; it would imply greater positive reinforcement from the drug, not the worsened aversive state that anti-reward emphasizes.
Option 4: 'Repeated drug use decreases the symptoms of withdrawal and tolerance (an aversive state)' — This would imply a dampening of withdrawal, opposite to the sensitization of the anti-reward system, which is characterized by worsened withdrawal and increased negative affect.
In sum, the central idea of drug-generated sensitization of anti-reward is that repeated exposure amplifies aversive states such as withdrawal and negative mood, which fosters compulsive use as a means to escape or mitigate those states. Therefore, option 2 is the one that coherently reflects this mechanism, while the others either invert or mischaracterize the relationship between repetition, reward, and aversive states.

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